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FLASH GENE

Symbol

GPR78

contributors: mct - updated : 18-05-2009

HGNC name	G protein-coupled receptor 78
HGNC id	4528

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.23 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080819 3 - 1955 NP_543009 39.2 363 - 2003 12975309

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	in developing brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane domain

HOMOLOGY

intraspecies

homolog to GPR26

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

basic FUNCTION	transducing extracellular signals through heterotrimeric G protein
	activate G proteins in a manner that is distinct from other group 1 GPCRs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to bipolar affective disorder and schizophrenia (BPAD and SCZ) in the Scottish population

Variant & Polymorphism SNP	increasing the risk of bipolar affective disorder and schizophrenia in females

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS