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FLASH GENE
Symbol GPR78 contributors: mct - updated : 18-05-2009
HGNC name G protein-coupled receptor 78
HGNC id 4528
DNA
TYPE functioning gene
STRUCTURE 7.23 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391618 4 hypothetical gene supported by NM_003875 FLJ20356 HTRA3 4p16.1 serine protease HTRA3 ACOX3 4p15.3 acyl-Coenzyme A oxidase 3, pristanoyl FLJ35725 4p16.1 hypothetical protein FLJ35725 FLJ12891 4p16.1 hypothetical protein FLJ12891 GPR78 4p16.1 G protein-coupled receptor 78 CPZ 4p16 carboxypeptidase Z LOC391619 4 similar to ubiquitin-specific protease 17-like protein LOC391620 4 similar to ubiquitin-specific protease 17-like protein LOC391621 4 similar to ubiquitin-specific protease 17-like protein LOC391622 4 similar to ubiquitin-specific protease 17-like protein LOC391623 4 similar to ubiquitin-specific protease 17-like protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1955 39.2 363 - 2003 12975309
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domain
  • HOMOLOGY
    intraspecies homolog to GPR26
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • transducing extracellular signals through heterotrimeric G protein
  • activate G proteins in a manner that is distinct from other group 1 GPCRs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bipolar affective disorder and schizophrenia (BPAD and SCZ) in the Scottish population
    Variant & Polymorphism SNP increasing the risk of bipolar affective disorder and schizophrenia in females
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS