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FLASH GENE
Symbol FMNL2 contributors: mct - updated : 01-03-2014
HGNC name formin-like 2
HGNC id 18267
Location 2q23.3      Physical location : 153.191.750 - 153.506.346
Synonym name formin homology 2 domain containing 2
Synonym symbol(s) KIAA1902, FHOD2, FRL3
DNA
TYPE functioning gene
STRUCTURE 314.66 kb     26 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5575 - 1092 - 2003 1268468
FMNL2A
- - 5685 - 1087 - 2003 1268468
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphatic vessel     Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivefemale systemplacenta    Homo sapiens
 female systembreastmammary gland   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneepithelial cell Homo sapiens
Nervousglia Homo sapiens
Nervousneuron Homo sapiens
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal FMNL2 drives elongation rather than nucleation of actin filaments in the presence of profilin
  • HOMOLOGY
    Homologene
    FAMILY formin protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text co-localizes with F-actin dots at the tips of cellular protrusions
    basic FUNCTION
  • actin binding activity
  • control the actin-dependent processes such as cell motility or invasion
  • is a positive regulator of cell motility, invasion, and metastasis of colorectal carcinoma
  • actin assembly factor that accelerate filament nucleation then remain on the elongating barbed end and modulate filament elongation
  • accumulates at lamellipodia and filopodia tips
  • is a novel elongation factor of actin filaments that constitutes the first CDC42 effector promoting cell migration and actin polymerization at the tips of lamellipodia
  • FMNL2 and FMNL3, are members of the formin family of proteins, were associated mainly with the plasma membrane and induced significant cellular morphological changes
  • protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3
  • DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cotranslationally modified by myristoylation and regulated by interaction with the RHO-guanosine triphosphatase CDC42
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma
    tumoral     --over  
    in metastatic cell lines and tissues of colorectal carcinoma is associated with more aggressive tumour behaviour
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS