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FLASH GENE
Symbol FMNL2 contributors: mct - updated : 01-03-2014
HGNC name formin-like 2
HGNC id 18267
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal FMNL2 drives elongation rather than nucleation of actin filaments in the presence of profilin
    • HOMOLOGY
    Homologene
    FAMILY formin protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text co-localizes with F-actin dots at the tips of cellular protrusions
    basic FUNCTION
  • actin binding activity
  • control the actin-dependent processes such as cell motility or invasion
  • is a positive regulator of cell motility, invasion, and metastasis of colorectal carcinoma
  • actin assembly factor that accelerate filament nucleation then remain on the elongating barbed end and modulate filament elongation
  • accumulates at lamellipodia and filopodia tips
  • is a novel elongation factor of actin filaments that constitutes the first CDC42 effector promoting cell migration and actin polymerization at the tips of lamellipodia
  • FMNL2 and FMNL3, are members of the formin family of proteins, were associated mainly with the plasma membrane and induced significant cellular morphological changes
  • protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3
  • DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cotranslationally modified by myristoylation and regulated by interaction with the RHO-guanosine triphosphatase CDC42
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma
    tumoral     --over  
    in metastatic cell lines and tissues of colorectal carcinoma is associated with more aggressive tumour behaviour
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS