| basic FUNCTION
| playing a role in cyclic GMP-dependent inhibition of VSMC stress fiber formation and/or migration |
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inducing transcription from SREs by multiple pathways |
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regulating gene transcription, actin-cytoskeleton structure, and cell migration |
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regulating cytoskeletal architecture, enhancing cell migration, and inducing gene expression from the serum response element |
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physically associates via the N-terminal part of its FH2 domain with the central domain of ROCK1 |
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playing a role in SH4 domain-induced blebbing and suggest that its activity is regulated by ROCK1 in a Src-dependent manner |
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plays potentially a major role in RHOA-dependent signaling in smooth muscle cell (SMC)  |
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lacks actin nucleation and elongation capacity, but acts as an actin bundling factor with capping activity toward the filament barbed end |
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combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers |
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not only caused morphology alteration but triggered the cells to switch to an elongated mesenchymal mode of motility |
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FHOD1 and the small GTPase RAC1 promote vaccinia virus actin-based motility (PMId: 24062339) |
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contributes to cell migration and invasion, and participates in cytoskeletal changes in EMT |
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recruited to integrin clusters, resulting in actin assembly |
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is needed for directed forces and adhesion maturation during cell spreading and migration |
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in cells, active FHOD1 stimulates the formation of ventral stress fibers |
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controls the formation of two distinct stress fiber precursors differentially |
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regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers |
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FHOD1 and INF2 are novel components and additional actin-based regulators of podosomes in primary human macrophages |
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FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes |
