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FLASH GENE
Symbol FHOD1 contributors: mct/npt - updated : 03-06-2014
HGNC name formin homology 2 domain containing 1
HGNC id 17905
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3865 - 1164 - Takeya (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta  highly Homo sapiens
Digestivesalivary gland   highly
Lymphoid/Immunespleen    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain
  • FH2 domain with a predicted coiled-coil motif
  • a GTPase-binding domain (GBD)
  • the DAD-recognition domain FH3 composed of five armadillo repeats, similarly to other formins
  • C-terminal formin homology FH1 (proline-rich)
  • HOMOLOGY
    interspecies homolog to murine Fhod1
    Homologene
    FAMILY formin/diaphanous family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in coronary artery, aortic smooth muscle cells, arterial and venous endothelial cells
    basic FUNCTION
  • playing a role in cyclic GMP-dependent inhibition of VSMC stress fiber formation and/or migration
  • inducing transcription from SREs by multiple pathways
  • regulating gene transcription, actin-cytoskeleton structure, and cell migration
  • regulating cytoskeletal architecture, enhancing cell migration, and inducing gene expression from the serum response element
  • physically associates via the N-terminal part of its FH2 domain with the central domain of ROCK1
  • playing a role in SH4 domain-induced blebbing and suggest that its activity is regulated by ROCK1 in a Src-dependent manner
  • plays potentially a major role in RHOA-dependent signaling in smooth muscle cell (SMC)
  • lacks actin nucleation and elongation capacity, but acts as an actin bundling factor with capping activity toward the filament barbed end
  • combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers
  • not only caused morphology alteration but triggered the cells to switch to an elongated mesenchymal mode of motility
  • FHOD1 and the small GTPase RAC1 promote vaccinia virus actin-based motility (PMId: 24062339)
  • contributes to cell migration and invasion, and participates in cytoskeletal changes in EMT
  • recruited to integrin clusters, resulting in actin assembly
  • is needed for directed forces and adhesion maturation during cell spreading and migration
  • in cells, active FHOD1 stimulates the formation of ventral stress fibers
  • controls the formation of two distinct stress fiber precursors differentially
  • regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers
  • FHOD1 and INF2 are novel components and additional actin-based regulators of podosomes in primary human macrophages
  • FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the Rho-GTPase Rac1 and mediates formation of actin stress fibers in its deregulated form
  • cyclic cGMP-dependent protein kinase I-binding protein
  • binding, by its carboxy-terminal two-thirds, with protein kinase C binding protein 1 (ZMYND8), cyclophilin B, and an isoform of WASP-interacting SH3-domain protein/diaphanous-interacting protein 1 NCKIPSD
  • interacting with PKG1alpha
  • interacting with the Rac GTPase and activates the Rho-ROCK cascade leading to the formation of actin stress fibers
  • SYNE2/FHOD1 interaction provided a second connection to actin cables essential for transmembrane actin-associated (TAN)line formation and thus nuclear movement
  • cell & other
    REGULATION
    activated by the small GTPase RAC1 (RAC11 was enriched and activated at the membrane surrounding actin tails)
    Other oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities
    phosphorylated on the C-terminal residues Ser1131, Ser1137, and Thr1141 by ROCK1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS