Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNAJB6 contributors: mct - updated : 08-02-2014
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 6
HGNC id 14888
Corresponding disease
LGMD1D limb-girdle muscular dystrophy 1D
Location 7q36.3      Physical location : 157.129.709 - 157.210.132
Synonym name
  • heat shock protein J2
  • dnaJ homolog subfamily B member 6
  • DnaJ-like 2 protein
  • limb girdle muscular dystrophy 1D (autosomal dominant)
  • Synonym symbol(s) MRJ, HHDJ1, HSJ-2, MSJ-1, MGC1152, MGC5201, DKFZp566D0824, MGC117297, DJ4, FLJ42837, Dnaj, MSJ1
    DNA
    TYPE functioning gene
    STRUCTURE 80.42 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392156 7 similar to ppg3 DPP6 7q dipeptidylpeptidase 6 PAXIP1L 7q36.3 PAX transcription activation domain interacting protein 1 like HTR5A 7q36.1 5-hydroxytryptamine (serotonin) receptor 5A LOC389601 7 LOC389601 INSIG1 7q36 insulin induced gene 1 EN2 7q36.2 engrailed homolog 2 LOC392157 7 similar to RIKEN cDNA 9630008K15 gene MGC20460 7q36.3 hypothetical protein MGC20460 SHH 7q36 sonic hedgehog homolog (Drosophila) LOC389602 7 hypothetical gene supported by AK124321 LOC346305 7q36.3 similar to hypothetical protein Tb927.2.4050 LOC285890 7q36.3 hypothetical LOC285890 C7orf13 7q36 chromosome 7 open reading frame 13 RNF32 7q36 ring finger protein 32 C7orf2 7q36 chromosome 7 open reading frame 2 C7orf3 7q36 chromosome 7 open reading frame 3 HLXB9 7q36 homeo box HB9 LOC392158 7 similar to S-adenosylmethionine decarboxylase KIAA0010 7q36.3 ubiquitin-protein isopeptide ligase (E3) DNAJB6 7q36.3 DnaJ (Hsp40) homolog, subfamily B, member 6 LOC392159 7 similar to polycystic kidney disease 1-like 3 LOC389603 7 hypothetical gene supported by AK098637 PTPRN2 7q36 protein tyrosine phosphatase, receptor type, N polypeptide 2 LOC285872 7q36.3 hypothetical gene supported by AL833137 FLJ20311 7q36.3 hypothetical protein FLJ20311 KIAA1228 7q36.3 hypothetical protein FLJ20311 FLJ10300 7q36.3 hypothetical protein FLJ10300 LOC392160 7 LOC392160 LOC392161 7 LOC392161 VIPR2 7q36.3 vasoactive intestinal peptide receptor 2 LOC154822 7q36.3 hypothetical protein LOC154822 LOC392162 7 similar to 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2494 36.1 326 - 2010 20522561
  • also called MRJ(L)
  • can act as a nuclear protein by virtue of its nuclear localization signal and can considerably reduce the expression of several secreted proteins that promote invasion, migration, and metastasis of cancer cells
  • inhibits Wnt/beta-catenin signaling by up-regulating DKK1, a secreted inhibitor of Wnt signaling
  • 8 splicing 1568 26.9 241 - 2010 20522561
  • also called MRJ(S)
  • regulate keratin8/k18 organization
  • assist in NFATc3-mediated transcriptional repression
  • play a critical role in Huntington disease
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a J domain
  • HOMOLOGY
    interspecies ortholog to murine Dnajb6
    Homologene
    FAMILY
  • DNAJ protein family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • dispersed throughout the cell during late mitosis and localized in nucleolus during interphase, confirming that the activity of DNAJC6 is regulated by its cell cycle specific expression together with its differential subcellular localization
  • basic FUNCTION
  • playing a role in oligomeric protein complex assembly
  • playing a role in polyglutamine aggregation in specific neurons
  • having a heat shock protein activity
  • might exert fundamental functions in reproduction
  • implicated in diverse cellular functions including placental development and inhibition of Huntingtin mediated cytotoxicity
  • with DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins
  • may play a role in maintaining an epithelial phenotype, and inhibition of the Wnt/beta-catenin pathway may be one of the potential mechanisms contributing to the restriction of malignant behavior by DNAJB6
  • DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides
  • is a peptide-binding chaperone that can interact with polyQ peptides that are incompletely degraded by and released from the proteasome
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PTTG
  • interacting with CFTR
  • interact with keratin intermediate filaments
  • regulatory mechanism of DNAJB6-mediated DKK1 transcriptional up-regulation that can influence EMT (epithelial-mesenchymal transition)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS