Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DGCR8

contributors: mct/npt/pgu - updated : 19-04-2017

HGNC name	microprocessor complex subunit
HGNC id	2847

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL22Q11 , DUP22Q11

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function resulted in smaller dendritic spines and simpler dendritic tree and impaired sensorimotor gating and acquisition of a spatial working memory–dependent task constitutional       loss of function associated with altered short-term plasticity and is a neural substrate underlying the cognitive dysfunction and the increased risk for schizophrenia associated with the 22q11.2 microdeletions tumoral       gain of function may be involved in tumorigenesis and aggressiveness of invasive ductal breast carcinoma (IDC) constitutional   deletion     conditional gene deletion of the essential miRNA-processing enzyme Dgcr8 in the developing renal tubular system results in severe developmental defects and kidney failure constitutional       loss of function senescence triggered by DGCR8 loss is accompanied by the upregulation of the cell-cycle inhibitor CDKN1A

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may serve as future therapeutic target in invasive ductal breast carcinoma (IDC)

ANIMAL & CELL MODELS

	Dgcr8+/- mice display reduced expression of a subset of microRNAs in the prefrontal cortex, a deficit that emerges over postnatal development
	deficiency in Dgcr8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice