| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
|
| loss of function
|
|
resulted in smaller dendritic spines and simpler dendritic tree and impaired sensorimotor gating and acquisition of a spatial working memory–dependent task |
| constitutional
|
|
|
| loss of function
|
associated with altered short-term plasticity and is a neural substrate underlying the cognitive dysfunction and the increased risk for schizophrenia associated with the 22q11.2 microdeletions  |
| tumoral
|
|
|
| gain of function
|
|
may be involved in tumorigenesis and aggressiveness of invasive ductal breast carcinoma (IDC) |
| constitutional
|
| deletion
|
|
|
|
conditional gene deletion of the essential miRNA-processing enzyme Dgcr8 in the developing renal tubular system results in severe developmental defects and kidney failure |
| constitutional
|
|
|
| loss of function
|
|
senescence triggered by DGCR8 loss is accompanied by the upregulation of the cell-cycle inhibitor CDKN1A |
