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FLASH GENE

Symbol

CTCFL

contributors: mct/pgu - updated : 13-04-2020

HGNC name	CCCTC-binding factor (zinc finger protein)-like
HGNC id	16234

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in juvenile angiofibroma in the posterior nasal cavity of adolescent males tumoral     --other   aberrantly expressed in melanoma tumoral     --over   in high-grade epithelial ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene	candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line
	potential practical applications as a molecular biomarker of breast cancer
Marker	aberrant CTCFL hypomethylation is a promising biomarker for the prognosis of hepatocellular carcinoma
Therapy target	has the potential to be used as a prognostic biomarker and to yield novel drug targets among the genes CTCFL controls in serous ovarian cancer (SOC) patients

ANIMAL & CELL MODELS

Mice homozygous for the null allele had a defect in spermatogenesis that resulted in small testes associated with increased cell death