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Symbol CTCFL contributors: mct/pgu - updated : 13-04-2020
HGNC name CCCTC-binding factor (zinc finger protein)-like
HGNC id 16234
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in juvenile angiofibroma in the posterior nasal cavity of adolescent males
tumoral     --other  
aberrantly expressed in melanoma
tumoral     --over  
in high-grade epithelial ovarian cancer
Variant & Polymorphism
Candidate gene
  • candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line
  • potential practical applications as a molecular biomarker of breast cancer
  • Marker
  • aberrant CTCFL hypomethylation is a promising biomarker for the prognosis of hepatocellular carcinoma
  • Therapy target
  • has the potential to be used as a prognostic biomarker and to yield novel drug targets among the genes CTCFL controls in serous ovarian cancer (SOC) patients
  • Mice homozygous for the null allele had a defect in spermatogenesis that resulted in small testes associated with increased cell death