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FLASH GENE
Symbol CNNM4 contributors: mct - updated : 28-12-2016
HGNC name cyclin M4
HGNC id 105
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved CBS forming a stable globular domain
  • four transmembrane domains
  • a sequence motif present in cyclin box
  • a cyclic nucleotide-monophosphate (cNMP)-binding domain
  • two cystathionine-beta-synthase (CBS) domains
  • a DUF21 domain
  • an ancient conserved domain” that is evolutionarily conserved in species (Polok 2008)
    • HOMOLOGY
    Homologene
    FAMILY
  • ACDP family
    • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text located on or close to the plasma membrane
    basic FUNCTION
  • implicated in metal ion transport
  • involved in the maturation of amelogenin
  • having a role in metal transport in biomineralization, wherein the protein could remove unwanted ions, such as magnesium, that are known to interfere with crystal formation in enamel
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with cytochrome oxydase 11 (COX11) to regulate metal ion homeostasis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CRDAI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS