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FLASH GENE
Symbol CNNM4 contributors: mct - updated : 28-12-2016
HGNC name cyclin M4
HGNC id 105
DNA
TYPE functioning gene
STRUCTURE 51.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC129872 2q11.2 similar to Glycerol-3-phosphate acyltransferase, mitochondrial precursor (GPAT) LOC150759 2q11.2 hypothetical protein LOC150759 LOC389006 2 similar to KIAA1641 protein LOC389007 2 similar to hypothetical protein LOC150763 2q11.2 hypothetical protein LOC150763 ADRA2B 2p13-q13 adrenergic, alpha-2B-, receptor LOC200515 2q11.2 similar to hypothetical protein 7420700F21 DUSP2 2q11 dual specificity phosphatase 2 STARD7 2q11.1 START domain containing 7 FLJ20507 2q11.2 hypothetical protein FLJ20507 CIAO1 2q11.2 hypothetical protein FLJ20507 U5-200KD 2q11.1 hypothetical protein FLJ20507 KIAA1754L 2q11.2 KIAA1754-like BRRN1 2q11.2 barren homolog (Drosophila) LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816 SEMA4C 2q11.1 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C LOC51252 2q11.2 hypothetical protein LOC51252 LOC391409 2 hypothetical gene supported by NM_138800 LOC375247 2q11.2 hypothetical LOC375247 DKFZp434N062 2q11.2 hypothetical protein DKFZp434N062 UNQ2430 2q11.2 ankyrin-related KIAA1641 2q11.2 KIAA1641 protein UBE3AP1 2q11.1 ubiquitin protein ligase E3A pseudogene 1 LOC389008 2 similar to KIAA1641 protein LOC151320 2q11.2 similar to autoantigen NOR-90 COX5B 2cen-q13 cytochrome c oxidase subunit Vb ACTR1B 2q11.1-q11.2 ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4814 - 775 - 2003 12657465
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord     Homo sapiens
Urinarykidneytubuleconvoluted tubuleproximal tubule  Other species
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveameloblast Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing tooth
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved CBS forming a stable globular domain
  • four transmembrane domains
  • a sequence motif present in cyclin box
  • a cyclic nucleotide-monophosphate (cNMP)-binding domain
  • two cystathionine-beta-synthase (CBS) domains
  • a DUF21 domain
  • an ancient conserved domain” that is evolutionarily conserved in species (Polok 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • ACDP family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text located on or close to the plasma membrane
    basic FUNCTION
  • implicated in metal ion transport
  • involved in the maturation of amelogenin
  • having a role in metal transport in biomineralization, wherein the protein could remove unwanted ions, such as magnesium, that are known to interfere with crystal formation in enamel
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with cytochrome oxydase 11 (COX11) to regulate metal ion homeostasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CRDAI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS