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FLASH GENE

Symbol

MCM8

contributors: mct/npt/pgu - updated : 10-01-2016

HGNC name	minichromosome maintenance complex component 8
HGNC id	16147

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     moderately   liver         Skin/Tegument skin       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage
cell lines	hepatocellular carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a MCM domain
	an ATP binding domain
	a zinc finger motif
	a Walker A-type NTP-binding site

HOMOLOGY

interspecies	homolog to rattus Rn 77418
	homolog to Drosophila rec
	ortholog to murine Mcm8

intraspecies

paralog to MCM9

Homologene

FAMILY

MCM family

CATEGORY

regulatory , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	colocalized with replication foci and RPA34 on replicating chromatin

basic FUNCTION	playing a role in DNA replication
	involved in the elongation step of DNA replication as a helicase facilitating the recruitment of RPA34 and stimulating the processivity of DNA polymerases at replication foci
	playing a role in S phase but the function is unknown
	required for efficient progression of replication forks, suggesting a role in DNA unwinding (DNA helicase)
	DNA-dependent ATPase activity
	having an essential role for DNA replication
	functions with other known replication proteins in processes which accompany DNA replication, especially initiation, and which are specifically adapted to suit higher eukaryotes
	with MCM9, are my be involved in DNA replication although their exact roles are unclear
	suggested to enable recruitment of CDC6 to replication origins
	during DNA interstrand crosslinks repair, MCM8 and MCM9 form nuclear foci that partly colocalize with RAD51
	implicated in DNA replication elongation
	MCM8 is required for the stability of MCM9 protein in mammalian cells
	participates in homologous recombination and dsDNA break repair
	in the germline, the MCM8-MCM9 complex is most likely required for the resolution of DSBs that occur during HR between homologous chromosomes in pachytene of meiosis I
	stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase

CELLULAR PROCESS	cell cycle
	nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	MCM8 and MCM9 form a complex and they coregulate their stability
	MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination

INTERACTION

DNA	binding chromatin upon initiation of DNA synthesis

RNA

small molecule	metal binding, nucleotide,
	ATP
	zinc Zn2+

protein	MCM4
	MCM6
	MCM7

cell & other

REGULATION

activated by

MYCN

ASSOCIATED DISORDERS

corresponding disease(s)

POF10

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

MCM8(-/-) mice are sterile because spermatocytes are blocked in meiotic prophase I, and females have only arrested primary follicles and frequently develop ovarian tumors