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FLASH GENE
Symbol MCM8 contributors: mct/npt/pgu - updated : 10-01-2015
HGNC name minichromosome maintenance complex component 8
HGNC id 16147
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 liver    
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines hepatocellular carcinoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a MCM domain
  • an ATP binding domain
  • a zinc finger motif
  • a Walker A-type NTP-binding site
  • HOMOLOGY
    interspecies homolog to rattus Rn 77418
    homolog to Drosophila rec
    ortholog to murine Mcm8
    intraspecies paralog to MCM9
    Homologene
    FAMILY
  • MCM family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text colocalized with replication foci and RPA34 on replicating chromatin
    basic FUNCTION
  • playing a role in DNA replication
  • involved in the elongation step of DNA replication as a helicase facilitating the recruitment of RPA34 and stimulating the processivity of DNA polymerases at replication foci
  • playing a role in S phase but the function is unknown
  • required for efficient progression of replication forks, suggesting a role in DNA unwinding (DNA helicase)
  • DNA-dependent ATPase activity
  • having an essential role for DNA replication
  • functions with other known replication proteins in processes which accompany DNA replication, especially initiation, and which are specifically adapted to suit higher eukaryotes
  • with MCM9, are my be involved in DNA replication although their exact roles are unclear
  • suggested to enable recruitment of CDC6 to replication origins
  • during DNA interstrand crosslinks repair, MCM8 and MCM9 form nuclear foci that partly colocalize with RAD51
  • implicated in DNA replication elongation
  • MCM8 is required for the stability of MCM9 protein in mammalian cells
  • participates in homologous recombination and dsDNA break repair
  • in the germline, the MCM8-MCM9 complex is most likely required for the resolution of DSBs that occur during HR between homologous chromosomes in pachytene of meiosis I
  • CELLULAR PROCESS cell cycle
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MCM8 and MCM9 form a complex and they coregulate their stability
  • MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination
  • INTERACTION
    DNA binding chromatin upon initiation of DNA synthesis
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • zinc Zn2+
  • protein
  • MCM4
  • MCM6
  • MCM7
  • cell & other
    REGULATION
    activated by MYCN
    ASSOCIATED DISORDERS
    corresponding disease(s) POF7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • MCM8(-/-) mice are sterile because spermatocytes are blocked in meiotic prophase I, and females have only arrested primary follicles and frequently develop ovarian tumors