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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

EPHB2

contributors: mct - updated : 27-01-2017

HGNC name	EPH receptor B2
HGNC id	3393

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in colorectal cancer tumoral somatic mutation       in prostate cancer in progression tumoral     --low   in transitional cell carcinoma of the bladder

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed tumor     dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth miscelleaneous pain   ephrinB2 siRNA could be a potential therapeutic agent for neuropathic pain

ANIMAL & CELL MODELS

deletions of the gene reveal its essential roles for conduit vessel development in mice, suggesting similar functions during human vascular development and deregulation in vascular malformations