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FLASH GENE
Symbol EPHB2 contributors: mct - updated : 27-01-2017
HGNC name EPH receptor B2
HGNC id 3393
Location 1p36.12      Physical location : 23.037.330 - 23.241.822
Synonym name
  • EPH-related tyrosine kinase receptor B2
  • extracellular signal-regulated kinase
  • developmentally-regulated eph-related tyrosine kinase
  • tyrosine-protein kinase TYRO5
  • tyrosine-protein kinase receptor EPH-3
  • elk-related tyrosine kinase
    • Synonym symbol(s) DRT, EPHT3, ERK, TYRO5, HEK5, CAPB, EPTH3, MGC87492, PCBC
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 204.49 kb     16 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 4869 - 987 - 2008 18713744
    precursor, isoform 2
    16 splicing 4866 - 986 - 2008 18713744
    precursor, isoform 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Lymphoid/Immunethymus     Homo sapiens
    Nervousbrainmidbrain    Homo sapiens
     braindiencephalonamygdala highly Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    Urinarybladder   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a vestigial Ig-I domain
  • a single cysteine rich region
  • two FNIII domains in the extracellular region
  • a highly hydrophobic portion upstream of the putative tyrosine kinase domain
  • a sterile alpha motif (SAM) domain (to self associate)
    • HOMOLOGY
    interspecies ortholog to murine Ephb2
    homolog to drosophila Eph
    Homologene
    FAMILY
  • Tyr protein kinase family
  • ephrin receptor subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • receptor tyrosine kinase, phosphorylating and interacting with RAS to control integrin activity
  • involved in short-range contact-mediated axonal guidance
  • likely involved in neurogenesis and oncogenesis (neuroblastoma, SCLC)
  • involved in cell migration and maintenance of normal tissue architecture
  • may modulate mTOR signaling
  • may play a critical role in TSC progression through phosphorylation and posttranslational inactivation of TSC2
  • inhibition of its cleavage also had potent regulatory effects on EPHB2 activity
  • plays an important role in maintaining the correct positioning of the proliferative compartment in the crypt-villous axis
  • induction of ephrinB2 might activate EPHB1/EPHBB2 signaling pathway to regulate synaptic plasticity and reorganization (Kobayashi 2007)
  • its expression on neural crest-derived cells is required for the migration of the thymic primordium to its normal position in the thoracic cavity
  • EPHB4 and EPHB2 play important roles in neovascularization and arteriovenous differentiation/plasticity
  • EPHB2, CDC42, and PAK3 are broadly capable of controlling dendritic spine formation and synaptic plasticity and are implicated in multiple cognitive disorders
    • CELLULAR PROCESS cell life
    cell organization/biogenesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • neuronal pathway linking stress-induced proteolysis of EPHB2 in the amygdala to anxiety
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ephrins B
  • involved as an important signaling molecule to mediate angiogenic effects of CXCL16 in umbilical vein endothelial cells
  • direct transcriptional target of beta-catenin/TCF
  • interaction with EPHB1 (neural crest -derived cell-specific role of EPHB1–EPHB2 interactions in the collective migration of the thymic rudiment during organogenesis)
  • KLK8 cleaves the extracellular portion of EPHB2 and facilitates the dynamic interaction of EPHB2 with the NR1 subunit of the NMDA receptor
  • RELN binds to the extracellular domains of EPHB1, EPHB2 transmembrane proteins, inducing receptor clustering and activation of EPHB forward signaling in neurons, independently of the 'classical' Reelin receptors, LRP8 and VLDLR
  • SPSB4 down-regulation enhances cell repulsive responses mediated by EPHB2 stimulation
    • cell & other
    REGULATION
    Other developmentally regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in colorectal cancer
    tumoral somatic mutation      
    in prostate cancer in progression
    tumoral     --low  
    in transitional cell carcinoma of the bladder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    tumor  
    dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth
    miscelleaneouspain 
    ephrinB2 siRNA could be a potential therapeutic agent for neuropathic pain
    ANIMAL & CELL MODELS
    deletions of the gene reveal its essential roles for conduit vessel development in mice, suggesting similar functions during human vascular development and deregulation in vascular malformations