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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

BMP8B

contributors: mct - updated : 22-02-2016

HGNC name	bone morphogenetic protein 8 b(osteogenic protein 2)
HGNC id	1075

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in pancreatic cancer tissue compared with the normal tissue adjacent to the tumors constitutional       loss of function substantially increases susceptibility to diet-induced obesity

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive pancreas potential therapeutic target for pancreatic cancer

ANIMAL & CELL MODELS

	Bmp8b-/- mice were viable and healthy but infertile due to defective primordial germ cell formation
	Bmp8b-/- mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia