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FLASH GENE
Symbol BMP8B contributors: mct - updated : 22-02-2016
HGNC name bone morphogenetic protein 8 b(osteogenic protein 2)
HGNC id 1075
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in pancreatic cancer tissue compared with the normal tissue adjacent to the tumors
constitutional       loss of function
substantially increases susceptibility to diet-induced obesity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivepancreas
potential therapeutic target for pancreatic cancer
ANIMAL & CELL MODELS
  • Bmp8b-/- mice were viable and healthy but infertile due to defective primordial germ cell formation
  • Bmp8b-/- mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia