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FLASH GENE
Symbol BMP8B contributors: mct - updated : 22-02-2016
HGNC name bone morphogenetic protein 8 b(osteogenic protein 2)
HGNC id 1075
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • a 19 acid amine signal sequence
  • a 244 residu propeptide with N-linked glycosylation
  • a 139 acid amine chain with three disulfide intrachain propeptide,a Cys with disulfide interchain and a N-linked glycosylation
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Bmp8a
    homolog to Drosophila scw
    homolog to C.elegans T25F10.2
    Homologene
    FAMILY transforming growth factor beta family
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • inducing cartilage and bone formation
  • playing a role in calcium regulation and bone homeostasis
  • is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK
  • role for BMP8B as a signaling molecule regulating thermogenesis and energy balance
  • is a fundamental component of energy balance regulation, particularly in response to nutritional changes
  • is involved in regulating the growth and apoptosis of pancreatic cancer cells
  • mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling signal transduction
    a component homodimer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by nutritional and thermogenic factors in mature brown adipose tissue (BAT), increasing the response to noradrenaline
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in pancreatic cancer tissue compared with the normal tissue adjacent to the tumors
    constitutional       loss of function
    substantially increases susceptibility to diet-induced obesity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    potential therapeutic target for pancreatic cancer
    ANIMAL & CELL MODELS
  • Bmp8b-/- mice were viable and healthy but infertile due to defective primordial germ cell formation
  • Bmp8b-/- mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia