| basic FUNCTION
| inhibiting the chaperone activity of Hsp 70/Hsc 70 by promoting substrate release and Hsp-mediated proteasomal degradation |
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antiapoptotic molecule induced by proteasome inhibitors in various cancer cells at the transcriptional level  |
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HSPB8 is responsible for recognizing the misfolded proteins whereas BAG3, at least in part through its proline-rich domain, might recruit and activate the macroautophagy machinery in close proximity to the chaperone-loaded substrates |
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forming complexes with BCL2, resulting in an enhancement of its anti-apoptotic activity and a decrease in the apoptosis induced via BAX or FAS |
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regulates motility and adhesion of epithelial cancer cells |
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responsible for macroautophagy stimulation |
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dual regulation of BAG3 in apoptosis suggests a key role for BAG3 in cancer cell resistance to apoptosis |
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Z-disk-associated protein, having antiapoptotic properties |
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co-chaperone that might prevent the accumulation of denatured proteins by regulating sHsp activity and by targeting their substrate proteins for degradation |
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has critical roles in regulating actin organization, cell adhesion, cell motility and tumor metastasis |
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could bind specific SH3-containing proteins that would allow BAG3 to play a role in signal transduction pathways (BAG3 associates with actin at the leading edge of migrating cells and controls cell motility) |
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mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins |
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having ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli |
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co-chaperone protein with antiapoptotic function, which localizes at Z-disc in the striated muscles |
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essential for the interaction between ERK and its phosphatase DUSP6, as a consequence its removal results in reduced binding of DUSP6 to ERK and sustained ERK phosphorylation and cell-cycle arrest in the G1 phase |
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regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma |
