Citations for
Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia.
Zhu H, Wu W, Fu Y, Shen W, Miao K, Hong M, Xu W, Young KH, Liu P, Li J.
Ann Hematol 93(3):425-35. doi: 10.1007/s00277-013-1883-1. Epub 2013 Aug 25. 2014
BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma.
Xiao H, Cheng S, Tong R, Lv Z, Ding C, Du C, Xie H, Zhou L, Wu J, Zheng S.
Lab Invest ab Invest. 2013 Dec 23. doi: 10.1038/labinvest.2013.151. [Epub ahead of print] 2013
BAG3 is upregulated by c-Jun and stabilizes JunD.
Li C, Li S, Kong DH, Meng X, Zong ZH, Liu BQ, Guan Y, Du ZX, Wang HQ.
Biochim Biophys Acta 1833(12):3346-54. doi: 10.1016/j.bbamcr.2013.10.007. Epub 2013 Oct 16. 2013
BAG3 mutations: another cause of giant axonal neuropathy.
Jaffer F, Murphy SM, Scoto M, Healy E, Rossor AM, Brandner S, Phadke R, Selcen D, Jungbluth H, Muntoni F, Reilly MM.
J Peripher Nerv Syst 17(2):210-6. doi: 10.1111/j.1529-8027.2012.00409.x. 2012
BAG3 controls angiogenesis through regulation of ERK phosphorylation.
Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, Nori SL, Nicolin V, Di Benedetto M, Vecchione ML, Arra C, Barbieri A, De Laurenzi V, Turco MC.
Oncogene 31(50):5153-61. doi: 10.1038/onc.2012.17. Epub 2012 Feb 6. 2012
Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer.
Zhang Y, Wang JH, Lu Q, Wang YJ.
Oncol Rep 27(1):109-13. doi: 10.3892/or.2011.1486. Epub 2011 Oct 3. 2012
Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy.
Norton N, Li D, Rieder MJ, Siegfried JD, Rampersaud E, Züchner S, Mangos S, Gonzalez-Quintana J, Wang L, McGee S, Reiser J, Martin E, Nickerson DA, Hershberger RE
Am J Hum Genet. 11;88(3):273-82. 2011
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C.
EMBO Rep 12(2):149-56. Epub 2011 Jan 21. 2011
Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes.
Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A.
Hum Mutat 32(12):1481-91. doi: 10.1002/humu.21603. Epub 2011 Sep 29. 2011
BAG3: a multifaceted protein that regulates major cell pathways.
Rosati A, Graziano V, De Laurenzi V, Pascale M, Turco MC.
Cell Death Dis 2:e141. doi: 10.1038/cddis.2011.24. Review. 2011
BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion.
Iwasaki M, Tanaka R, Hishiya A, Homma S, Reed JC, Takayama S.
Biochem Biophys Res Commun 400(3):413-8. Epub 2010 Aug 26. 2010
The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.
Virador VM, Davidson B, Czechowicz J, Mai A, Kassis J, Kohn EC.
PLoS One 4(4):e5136. Epub 2009 Apr 8. 2009
Mutation in BAG3 causes severe dominant childhood muscular dystrophy.
Selcen D, Muntoni F, Burton BK, Pegoraro E, Sewry C, Bite AV, Engel AG.
Ann Neurol 65(1):83-9. 2009
Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.
Fuchs M, Poirier DJ, Seguin SJ, Lambert H, Carra S, Charette SJ, Landry J.
Biochem J 425(1):245-55. Erratum in: Biochem J. 2010 Aug 27;430(3):559. PMID: 19845507 2009
15BAG3, HSF1
Bag3 gene expression is regulated by heat shock factor 1.
Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco MC, Pascale M.
J Cell Physiol 215(3):575-7. 2008
Transcriptional upregulation of BAG3 upon proteasome inhibition.
Wang HQ, Liu HM, Zhang HY, Guan Y, Du ZX.
Biochem Biophys Res Commun 365(2):381-5. Epub 2007 Nov 8. 2008
HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.
Carra S, Seguin SJ, Landry J.
Autophagy 4(2):237-9. Epub 2007 Dec 11. Review.PMID: 18094623 2008
BAG3 regulates motility and adhesion of epithelial cancer cells.
Iwasaki M, Homma S, Hishiya A, Dolezal SJ, Reed JC, Takayama S.
Cancer Res 67(21):10252-9. 2007
Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity.
Pagliuca MG, Lerose R, Cigliano S, Leone A.
FEBS Lett 541(1-3):11-5. 2003
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Doong H, Rizzo K, Fang S, Kulpa V, Weissman AM, Kohn EC.
J Biol Chem 278(31):28490-500. Epub 2003 May 14. 2003
21BAG3, BAG4, BAG1
Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.
Antoku K, Maser RS, Scully WJ Jr, Delach SM, Johnson DE.
Biochem Biophys Res Commun 286(5):1003-10. 2001
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gammaand Hsp70/Hsc70.
Doong H, Price J, Kim YS, Gasbarre C, Probst J, Liotta LA, Blanchette J,Rizzo K, Kohn E.
Oncogene 19(38):4385-95. 2000
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperoneregulators.
Takayama S, Xie Z, Reed JC.
J Biol Chem 274(2):781-6. 1999
Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing celldeath.
Lee JH, Takahashi T, Yasuhara N, Inazawa J, Kamada S, Tsujimoto Y.
Oncogene 18(46):6183-90. 1999