| basic FUNCTION
| interacting with Ku70 but not likely involved in DNA double strand repairs by non homologous end-joining |
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maybe modulating C-loops function at telomeres |
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regulating mitotic recombination |
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mediating the annealing of complementary single-strand DNA molecules |
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maintains genomic stability by bridging DNA ends and initiating DNA damage signaling through activation of the ATM kinase |
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nucleolytic processing by MRE11A is an essential function of fundamental importance in DNA repair, distinct from MRN control of ATM signaling |
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having structural and enzymatic contributions within the DSB repair complex to the biological needs for both creating and controlling proper 3-OH ends to prime DNA repair synthesis |
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key enzyme in DNA double-strand break repair and genome stability  |
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can favor alternative nonhomologous end joining through its nuclease activity |
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influences the cellular response to telomere dysfunction, reminiscent of its influence on the resposne to interstitial DNA breaks, and may promote telomeric DNA end processing during DNA replication |
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MRE11/RAD50/NBS1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double-strand breaks (DSBs) |
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ATM has a critical regulatory function in controlling DNA end-stability and error-prone DSB repair and MRE11A nuclease plays a major role in initiating microhomology-mediated end joining in cells, particularly in neuronal cells, which are post-mitotic |
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given that MRE11A dimers cooperate to bind DNA and DNA is also bound across both MRE11A protomers, a structural modulation in the MRE11A dimer would be an ideal mechanism to provide the dsDNA melting activity and position DNA into the active site for endo/exonucleolytic cleavage |
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MRE11 complex, specifically through its nuclease activity, implicated in fork degradation in the absence of BRCA2 |
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critical participant in upkeep of nuclear DNA, its repair, replication, meiosis, and maintenance of telomeres |
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potential role in the maintenance of genome integrity in mitochondria in addition to its previously known role in maintenance of nuclear DNA |
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is most likely involved with the MMR (DNA mismatch repair) pathway in a more complex fashion than simply being a MMR target gene |
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plays an important role in repairing damaged DNA by cleaving broken ends and by providing a platform for other DNA repair proteins |
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ATP hydrolysis opens the RAD50-MRE11A complex, and MRE11A maintains exonuclease activity |
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ATP hydrolysis is a molecular switch that converts MRE11A from an endonuclease to an exonuclease |
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serves as a cytosolic sensor for Double-stranded DNA (dsDNA) |
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contributes to recognition of a broad spectrum of dsDNA and the contribution of MRE11A is not restricted to certain cell types |
