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FLASH GENE

Symbol

TDP1

contributors: mct/npt/pgu - updated : 27-11-2015

HGNC name	tyrosyl-DNA phosphodiesterase 1
HGNC id	18884

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCAN1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   sensitizes human cells to alkylation damage and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitivity above that observed for TDP1 or APE1 depletion alone

Susceptibility

To Tourette syndrome (TS)

Variant & Polymorphism other	polymorphism at position rs28365054 in the TDP1 gene had a significant difference between the TS patients (AG genotype was a risk factor for TS)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS