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FLASH GENE
Symbol TDP1 contributors: mct/npt/pgu - updated : 27-11-2015
HGNC name tyrosyl-DNA phosphodiesterase 1
HGNC id 18884
ASSOCIATED DISORDERS
corresponding disease(s) SCAN1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
sensitizes human cells to alkylation damage and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitivity above that observed for TDP1 or APE1 depletion alone
Susceptibility To Tourette syndrome (TS)
Variant & Polymorphism other
  • polymorphism at position rs28365054 in the TDP1 gene had a significant difference between the TS patients (AG genotype was a risk factor for TS)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS