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FLASH GENE

Symbol

PARVG

contributors: - updated : 19-03-2005

HGNC name	parvin, gamma
HGNC id	14654

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	downregulated in embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two calponin-homology (CM) domains

HOMOLOGY

interspecies	ortholog to murine Parvg
	ortholog to Drosophila Cg12533
	ortholog to C.elegans Pat-6

intraspecies	paralog to PARVA
	paralog to PARVB

Homologene

FAMILY

parvin family of focal adhesion proteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	located to focal adhesions

basic FUNCTION

playing a role in the regulation of cell adhesion and cytoskeleton organsation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to ILK and actin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS