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FLASH GENE

Symbol

HTR3B

contributors: mct - updated : 02-04-2007

HGNC name	5-hydroxytryptamine (serotonin) receptor 3B
HGNC id	5298

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four transmembrane segments (4TM)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee HTR3B (98.85 pc)
	homolog to rattus Htr3b (73.21 pc)
	homolog to murine Htr3b (73.90 pc)

Homologene

FAMILY

CATEGORY

receptor membrane ligand ion channel , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	coexpressed with HTR3A

basic FUNCTION	biogenic hormone functioning as a neurotransmitter, a hormone, and a mitogen
	causes fast, depolarizing responses in neurons after activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission

neuronal transmission

a component

component of HTR3 receptor heterodimerizing with HTR3A to form a fully functional receptor with a large single channel conductance, mediating rapid excitatory responses

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to bipolar affective disorder to major depression

Variant & Polymorphism SNP , other	SNP influencing development of bipolar affectve disorder
	Y129S exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS