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FLASH GENE
Symbol HTR3B contributors: mct - updated : 02-04-2007
HGNC name 5-hydroxytryptamine (serotonin) receptor 3B
HGNC id 5298
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1847 50 441 small intestine, colon Tzvetkov
  • first variant described
  • - - - - - central nervous system Tzvetkov
  • lacking exon 1
  • upstream extended exon 2
  • potential start codon in extended exon 2
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Lymphoid/Immunelymph node    
    Nervousbraindiencephalonamygdala  
     brainbasal nucleicaudate nucleus  
     braindiencephalonhypothalamus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    four transmembrane segments (4TM)
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee HTR3B (98.85 pc)
    homolog to rattus Htr3b (73.21 pc)
    homolog to murine Htr3b (73.90 pc)
    Homologene
    FAMILY
    CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text coexpressed with HTR3A
    basic FUNCTION
  • biogenic hormone functioning as a neurotransmitter, a hormone, and a mitogen
  • causes fast, depolarizing responses in neurons after activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    neuronal transmission
    a component component of HTR3 receptor heterodimerizing with HTR3A to form a fully functional receptor with a large single channel conductance, mediating rapid excitatory responses
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to bipolar affective disorder
  • to major depression
  • Variant & Polymorphism SNP , other
  • SNP influencing development of bipolar affectve disorder
  • Y129S exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS