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FLASH GENE

Symbol

SFMBT1

contributors: mct - updated : 21-10-2014

HGNC name	Scm-like with four mbt domains 1
HGNC id	20255

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Nervous brain         Reproductive female system breast mammary gland   highly   male system testis     highly Respiratory lung       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four MBT repeats, sufficient and necessary for nuclear matrix attachment, transcriptional repression and histone binding, that may potentially bind methyl lysines
	a C2-C2 zinc finger
	a SAM (sterile alpha motif) domain

HOMOLOGY

interspecies	homolog to Drosophila sex comb on midleg (scm)
	homolog to murine Sfmbt1

intraspecies

homolog to SCML2

Homologene

FAMILY

malignant brain tumor (MBT) domain-containing protein family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	localized to the nucleus where it strongly associates with chromatin by directly and selectively binding the N-terminal tail of histone H3

basic FUNCTION	may be implicated in the regulation of transcription
	may be an important regulator of transcriptional programs during developmental and differentiation processes
	essential role of SFMBT1 in regulating MYOD1-mediated transcriptional silencing that is required for the maintenance of undifferentiated states of myogenic progenitor cells
	critical role of SFMBT1 in epigenetic regulation, EMT, and cancer
	is essential for SNAI1-mediated transcriptional repression

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

is a novel, integral component of the KDM1A complex

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein	strongly interacts with the nuclear matrix and also selectively binds histones H3 and H4
	regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with KDM1A and RCOR1
	SFMBT1 associates with the KDM1A complex and is essential for its chromatin association, histone demethylation, and induction of EMT
	is essential for SNAI1-dependent recruitment of KDM1A to chromatin, demethylation of H3K4me2, transcriptional repression of epithelial markers, and induction of EMT by TGFB1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS