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FLASH GENE
Symbol SFN contributors: mct/npt/pgu - updated : 26-06-2012
HGNC name stratifin
HGNC id 10773
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in mammary carcinoma by hypermethylation and invulval squamous neoplasia
tumoral     --low  
in prostate cancer
tumoral     --low  
involved in the uncontrolled cell cycle in intrahepatic cholangiocarcinoma and is a significant indicator of poor prognosis for patients with intrahepatic cholangiocarcinoma
tumoral     --over  
in gastric cancer, significantly correlated with clinical stage and tumor invasion
tumoral     --over  
hypomethylation of the promoter leads to increased expression in non-small cell lung cancer
tumoral        
epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivestomach
therapeutic molecular target for gastric cancer
ANIMAL & CELL MODELS