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FLASH GENE
Symbol SFN contributors: mct/npt/pgu - updated : 10-12-2024
HGNC name stratifin
HGNC id 10773
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in mammary carcinoma by hypermethylation and invulval squamous neoplasia
tumoral     --low  
in prostate cancer
tumoral     --low  
involved in the uncontrolled cell cycle in intrahepatic cholangiocarcinoma and is a significant indicator of poor prognosis for patients with intrahepatic cholangiocarcinoma
tumoral     --over  
in gastric cancer, significantly correlated with clinical stage and tumor invasion
tumoral     --over  
hypomethylation of the promoter leads to increased expression in non-small cell lung cancer
tumoral        
epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program
tumoral     --over  
aberrant overexpression of SFN (stratifin) plays an oncogenic role in lung adenocarcinoma
tumoral     --over  
in ovarian cancers is significantly correlated with worse postprogression survival
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • GORASP2 wuith SFN and ZYG11A, are prognostic biomarker for early stage lung adenocarcinoma
  • is a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma
  • hypermethylation, and reduced SFN mRNA expression both are potential biomarkers for identifying high-risk ocular surface squamous neoplasia patients
  • SFN is a potential biomarker for the diagnosis of perineural invasion (PNI) in stage II Colorectal carcinoma patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic molecular target for gastric cancer
    cancerlung 
    SFN inhibitors would be novel and promising antitumor drugs for lung adenocarcinoma
    ANIMAL & CELL MODELS