| basic FUNCTION
| may be involved in negative regulation of protein kinase activity, cell proliferation, signal transduction, regulation of cell cycle |
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implicated in G2/M cell cycle arrest by Tp53 (Kuroda 2007) |
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acts as a tumor suppressor and is often inactivated during tumor development  |
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having function linked to epidermal stratification and differentiation in the skin (Xin 2010) |
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critical for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity (Xin 2010) |
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important G2M cell cycle checkpoint regulator and its expression is induced by DNA damage stress through a TP53-dependent pathway (Xin 2010) |
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regulates corneal epithelial cell proliferation and differentiation by maintaining Notch activity (Xin 2010) |
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plays a critical role in retaining epithelial polarity, through its interaction with PARD3 (Ling 2010) |
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plays a critical role in retaining epithelial polarity |
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regulates cytokinesis and cell cycle arrest induced by DNA damage |
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maintains FOXO1 at a consistent level critical for normal B-cell antigen receptor signaling and B-cell survival |
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its levels are critical for maintaining TP53 activity in response to DNA damage and regulating signal mediators such as AKT1 |
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TP63 and SFN play opposing roles in the development of skin tumors and the accumulation of TP63 is essential for Ras/SFN mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis |
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intracellular, phosphoserine binding protein, playing a regulatory role in epidermal epithelial differentiation |
