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FLASH GENE

Symbol

CASP12

contributors: shn - updated : 17-11-2009

HGNC name	caspase 12 (gene/pseudogene)
HGNC id	19004

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function with HSPA5 were upregulated in cardiomyocytes in the diastolic heart failure resulting from hypertension )

Susceptibility

may constitute a risk factor for developing sepsis (Saleh 2004)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

caspase-12 deficiency mouse exhibits enhanced vulnerability to bacterial infection and septic mortality (Saleh 2006)