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FLASH GENE
Symbol ACTR3 contributors: mct/pg - updated : 09-07-2019
HGNC name ARP3 actin-related protein 3 homolog (yeast)
HGNC id 170
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Actr3
homolog to Drosophila arp66B
homolog to C.elegans Y71F9AL.16
intraspecies homolog to ARP3
Homologene
FAMILY
  • actin family
  • ARP3 subfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text actin cytoskeleton associated
    basic FUNCTION
  • being essential to cell shape and motility through lamellipodial actin assembly and protrusion
  • expression of EPS8 and ACTR3 are stage-specific during the seminiferous epithelial cycle of spermatogenesis, and these proteins localized predominantly at the apical and basal ectoplasmic specialization
  • ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
  • close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
  • WASF2–ACTR2/ACTR3 as necessary for myosin II recruitment and tension generation at the zonula adherens
    • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major constituent of the ARP2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC), that nucleates and cross-links actin filaments at the leading edge of motile cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in rat, high expression of Arp3 at the apical apical ectoplasmic specialization was shown to correlate with spermatid movement and proper spermatid orientation