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FLASH GENE
Symbol ACTR3 contributors: mct/pg - updated : 09-07-2019
HGNC name ARP3 actin-related protein 3 homolog (yeast)
HGNC id 170
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2728 47 418 - PMID: 18516090
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
 liver   highly
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
Reproductivemale systemmale genital tractseminiferous tubule highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Actr3
homolog to Drosophila arp66B
homolog to C.elegans Y71F9AL.16
intraspecies homolog to ARP3
Homologene
FAMILY
  • actin family
  • ARP3 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text actin cytoskeleton associated
    basic FUNCTION
  • being essential to cell shape and motility through lamellipodial actin assembly and protrusion
  • expression of EPS8 and ACTR3 are stage-specific during the seminiferous epithelial cycle of spermatogenesis, and these proteins localized predominantly at the apical and basal ectoplasmic specialization
  • ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
  • close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
  • WASF2–ACTR2/ACTR3 as necessary for myosin II recruitment and tension generation at the zonula adherens
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major constituent of the ARP2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC), that nucleates and cross-links actin filaments at the leading edge of motile cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in rat, high expression of Arp3 at the apical apical ectoplasmic specialization was shown to correlate with spermatid movement and proper spermatid orientation