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FLASH GENE

Symbol

ACTR3

contributors: mct/pg - updated : 09-07-2019

HGNC name	ARP3 actin-related protein 3 homolog (yeast)
HGNC id	170

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive esophagus       highly   liver       highly Endocrine adrenal gland       highly Lymphoid/Immune spleen       highly Reproductive male system male genital tract seminiferous tubule   highly   male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive Sertoli cell Reproductive spermatid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Actr3
	homolog to Drosophila arp66B
	homolog to C.elegans Y71F9AL.16

intraspecies

homolog to ARP3

Homologene

FAMILY	actin family
	ARP3 subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microfilament
text	actin cytoskeleton associated

basic FUNCTION	being essential to cell shape and motility through lamellipodial actin assembly and protrusion
	expression of EPS8 and ACTR3 are stage-specific during the seminiferous epithelial cycle of spermatogenesis, and these proteins localized predominantly at the apical and basal ectoplasmic specialization
	ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
	close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
	WASF2–ACTR2/ACTR3 as necessary for myosin II recruitment and tension generation at the zonula adherens

CELLULAR PROCESS	cell organization/biogenesis
	cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

major constituent of the ARP2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC), that nucleates and cross-links actin filaments at the leading edge of motile cells

INTERACTION

DNA

RNA

small molecule

protein	binding to actin
	interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in rat, high expression of Arp3 at the apical apical ectoplasmic specialization was shown to correlate with spermatid movement and proper spermatid orientation