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FLASH GENE
Symbol VPS41 contributors: mct - updated : 21-11-2022
HGNC name vacuolar protein sorting 41 homolog (S. cerevisiae)
HGNC id 12713
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 7-fold repeat common to clathrin and VPS proteins (two repeats)
  • an ATP/GTP site
  • a RING zinc finger motif
    • HOMOLOGY
    Homologene
    FAMILY
  • VPS41 family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text intracellular vesicles that originated from Golgi and shoned partial coincidence with the delta subunit of adaptor protein complex-3
    basic FUNCTION
  • formation and fusion of transport vesicles from the Golgi
  • both VPS41 and VPS39 are required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes in human cells
  • VPS41 and VAMP7 are specifically involved in the fusion of trans-Golgi network-derived lysosome-associated membrane protein carriers with late endosomes
  • self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway
  • VPS41 is required for insulin secretory granules (SGs) biogenesis and regulated insulin secretion, and contributes to glucose homeostasis and metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • WDR91 competes with the VPS41 subunit of the HOPS complex, another RAB7 effector, for binding to RAB7, thereby facilitating RAB7-dependent lysosome fusion in a controlled manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR29
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a deletion of Vps41 specifically in beta-cells develop diabetes due to severe depletion of insulin SG content and a defect in insulin secretion