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FLASH GENE

Symbol

LAT

contributors: mct/npt/pgu - updated : 30-08-2017

HGNC name	linker for activation of T cells
HGNC id	18874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD52

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   lower in asthmatic patients than that in healthy people

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

T cells from mice harboring a mutation at the Plcg1 binding site of Lat (Y136F) have impaired calcium flux and Erk activation, and these T cells are highly activated, resulting in the development of a lymphoproliferative syndrome