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FLASH GENE
Symbol LAT contributors: mct/npt/pgu - updated : 30-08-2017
HGNC name linker for activation of T cells
HGNC id 18874
ASSOCIATED DISORDERS
corresponding disease(s) IMD52
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
lower in asthmatic patients than that in healthy people
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • T cells from mice harboring a mutation at the Plcg1 binding site of Lat (Y136F) have impaired calcium flux and Erk activation, and these T cells are highly activated, resulting in the development of a lymphoproliferative syndrome