basic FUNCTION
| playing a critical role for the differentiation and homeostasis of T-helpers type 2 cells |
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localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins |
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transmembrane adaptor protein with a role in the development, activation, and maintenance of T cells |
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linker protein essential for activation of T lymphocytes |
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LAT and the linker for activation of B cells (LAB/NTAL/LAT2) are integral proteins in receptor coupling to downstream events |
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adaptor protein that couples TCR engagement to downstream signaling cascades |
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also plays an essential role in thymocyte development during transition from the double-positive to single-positive stage |
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plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of T-cell signals from the plasma membrane to the cellular interior |
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transmembrane adaptor protein that is essential to bridge T cell receptor (TCR) engagement to downstream signaling events |
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LAT-mediated signaling intricately regulates cytotoxic-T-lymphocyte (CTL) cytotoxicity at multiple steps |
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is proteolytically cleaved following FAS engagement in a tyrosine phosphorylation-dependent fashion |
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is a transmembrane adaptor protein that is vital for integrating TCR-mediated signals to modulate T cell development, activation, and proliferation |
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key adaptor in the T cell receptor (TCR) signaling pathway |
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transmembrane adaptor protein that is highly tyrosine phosphorylated upon engagement of the TCR |
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LAT, like CD247 and ZAP70, plays likely a role in neurogenesis and that perturbation of this pathway may lead to neurodevelopmental phenotypes |