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FLASH GENE
Symbol MUC5AC contributors: mct - updated : 27-11-2024
HGNC name mucin 5, subtypes A and C, tracheobronchial/gastric
HGNC id 7515
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal neoplasia and in intra-epithelial cancer of the pancreas
tumoral     --over  
in the ductal region of human pancreatic cancer
tumoral     --over  
in benign biliary disease, and biliary tract cancers 2)
tumoral     --low  
significantly correlated with poor overall survival of gastric cancer patients
constitutional       loss of function
results in impaired and discoordinated mucociliary transport, respectively, demonstrating the importance of each mucin to airway clearance
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • decreased MUC5AC expression might be a poor prognostic predictor for gastric cancer
  • potential diagnostic, prognostic and therapeutic target for various malignancies
  • overexpression of MUC5AC is a poor prognostic marker in lung cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential therapeutic target for various malignancies
    respiratorylung 
    inhibiting MUC5AC may be effective for treating asthma and other lung diseases where it is also overproduced
    ANIMAL & CELL MODELS