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FLASH GENE

Symbol

TACSTD2

contributors: mct/shn - updated : 21-06-2023

HGNC name	tumor-associated calcium signal transducer 2
HGNC id	11530

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002353 1 - 2080 NP_002344 35 323 - 1999 10192395

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Reproductive female system ovary     highly   male system prostate     highly Respiratory respiratory tract larynx     highly Urinary kidney         Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining epidermis stratum basale   Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage	normal trophoblast cells
cell lines	carcinoma cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	trophoblast, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single transmembrane domain
	EGF-like and thyroglobulin repeats
	four potential N-linked glycosylation sites
	a phosphatidylinositol binding site

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to Tacstd2, Mus musculus
	ortholog to Tacstd2, Rattus norvegicus
	ortholog to TACSTD2, Pan troglodytes

intraspecies

homolog to GA733.2

Homologene

FAMILY

thyroglobulin type-1 family

CATEGORY

adhesion , tumor suppressor , signaling

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	may play a role in regulating the growth of carcinoma cells (
	carcinoma associated antigen
	transducing an intracellular calcium signal and acting as a cell surface receptor
	functioning as a cell/cell adhesion receptor in cancer cells and as a calcium signal transducer
	its expression is necessary for tumorigenesis and invasiveness of colon cancer cells
	activating a molecular signaling pathway which has important implications for cancer cell growth and survival
	its upregulation quantitatively stimulates human cancer growth
	is a transmembrane signal transducer that can induce cancer growth
	TACSTD2 was able to compensate for the loss of EPCAM in stabilizing CLDN7 expression and cell membrane localization in tissues that co-express both proteins

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction , sensory transduction/vision

calcium signal tranducer

a component

INTERACTION

DNA

RNA

small molecule

protein	non-structural 5A, NS5A
	binding of LGALS3 to MUC1 enhances likely the recruitment of SP1, leading to promotion of the transcription of TACSTD2
	TACSTD2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis
	can tightly interact with ADAM10
	TACSTD2 was able to compensate for the loss of EPCAM in stabilizing CLDN7 expression and cell membrane localization in tissues that co-express both proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GDLD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with CCND1 and overexpressed in cancer cells tumoral     --over   in epithelial ovarian cancer tumoral     --over   correlates with poor prognosis in pancreatic cancer ( constitutional     --over   may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs tumoral     --over   are predictive of recurrence of localized prostate cancer, castration-resistant prostate cancer (CRPC), or neuroendocrine prostate cancer (NEPC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could be a novel prognostic biomarker for pancreatic cancer (
	could be used as a marker for pathological grading of squamous cell carcinoma (SCC)
	TACSTD2 may be a valuable prognosis predictive biomarker in human solid tumors
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary targeting of its overexpression by immunotherapeutic strategies may represent an attractive and potentially effective approach in patients harbouring epithelial ovarian cancer cancer endocrine pancreas might be a useful treatment approach for patients with pancreatic cancer overexpressing this cell-surface marker cancer     oncogene that has potential as a therapeutic target, and having a restricted expression in normal tissue, anti-Trop-2 therapeutics would be predicted to have limited toxicity cancer reproductive prostate is a driver and therapeutic target for metastatic prostate cancer with neuroendocrine phenotype cancer digestive colon is a target in metastatic colon cancer cancer     potential therapeutic target in human solid tumors

ANIMAL & CELL MODELS