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FLASH GENE
Symbol EPSTI1 contributors: npt/mct - updated : 25-10-2016
HGNC name epithelial stromal interaction 1 (breast)
HGNC id 16465
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • as a hitherto unappreciated regulator of tumor cell properties
  • PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLF8 promoted the EPSTI1 expression by directly acting on the EPSTI1 gene promoter
    • cell & other
    REGULATION
    induced by by epithelial-stromal interaction in human breast cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS