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FLASH GENE

Symbol

CFHR5

contributors: mct - updated : 27-06-2018

HGNC name	complement factor H-related 5
HGNC id	24668

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HUS3 , C3G3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion       CFHR5-CFHR2 fusion gene in familial C3 glomerulonephritis

Susceptibility

to membranoproliferative glomerulonephritis type II(dense deposit disease) to IgAN (IgA nephropathy)

Variant & Polymorphism SNP	increasing the risk of membranoproliferative glomerulonephritis type II(dense deposit disease)
	contribution of rare variants of the CFHR5 gene to IgAN susceptibility

Candidate gene
Marker	circulating CFHR5 level is an independent risk factor for IgAN progression
Therapy target

ANIMAL & CELL MODELS