Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CFHR5 contributors: mct - updated : 27-06-2018
HGNC name complement factor H-related 5
HGNC id 24668
Corresponding disease
HUS3 hemolytic-uremic syndrome, atypical 3
Location 1q31.3      Physical location : 196.946.666 - 196.978.801
Synonym name factor H-related protein 5
Synonym symbol(s) FHR-5, FHR5, FLJ10549, CFHL5
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine sushi domains (SCR repeat)
  • nine short consensus repeat motifs
  • one immunoglobulin-like c2-type domain
  • HOMOLOGY
    intraspecies homolog to HF1,HF2
    Homologene
    FAMILY complement factor H (CFH) family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a role in the development of CNS functions involved in locomotor activity
  • possesses cofactor activity and has been proposed to play a role in complement regulation in the glomerulus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of immune deposits in kidney with sclerotic lesions from different causes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HUS3
    Susceptibility to membranoproliferative glomerulonephritis type II(dense deposit disease)
    Variant & Polymorphism SNP increasing the risk of membranoproliferative glomerulonephritis type II(dense deposit disease)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS