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FLASH GENE

Symbol

CFHR5

contributors: mct - updated : 27-06-2018

HGNC name	complement factor H-related 5
HGNC id	24668

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HUS3 hemolytic-uremic syndrome, atypical 3
Location	1q31.3      Physical location : 196.946.666 - 196.978.801
Synonym name	factor H-related protein 5
Synonym symbol(s)	FHR-5, FHR5, FLJ10549, CFHL5

DNA

TYPE	functioning gene
STRUCTURE	32.00 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nine sushi domains (SCR repeat)
	nine short consensus repeat motifs
	one immunoglobulin-like c2-type domain

HOMOLOGY

intraspecies

homolog to HF1,HF2

Homologene

FAMILY

complement factor H (CFH) family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	having a role in the development of CNS functions involved in locomotor activity
	possesses cofactor activity and has been proposed to play a role in complement regulation in the glomerulus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of immune deposits in kidney with sclerotic lesions from different causes

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HUS3

Susceptibility

to membranoproliferative glomerulonephritis type II(dense deposit disease)

Variant & Polymorphism SNP	increasing the risk of membranoproliferative glomerulonephritis type II(dense deposit disease)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS