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FLASH GENE

Symbol

TRPM1

contributors: mct/shn - updated : 14-06-2016

HGNC name	transient receptor potential cation channel, subfamily M, member 1
HGNC id	7146

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CSNB1C

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in melanoma with high metastatic potential

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	potential target for pigmentation disorders

ANIMAL & CELL MODELS

	decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both congenital stationary night blindness and coat spotting patterns in horses
	ON bipolar cell function was absent or severely impaired in a mouse model that lacked Trpm1 expression