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FLASH GENE
Symbol TRPM1 contributors: mct/shn - updated : 14-06-2016
HGNC name transient receptor potential cation channel, subfamily M, member 1
HGNC id 7146
ASSOCIATED DISORDERS
corresponding disease(s) CSNB1C
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in melanoma with high metastatic potential
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • potential target for pigmentation disorders
  • ANIMAL & CELL MODELS
  • decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both congenital stationary night blindness and coat spotting patterns in horses
  • ON bipolar cell function was absent or severely impaired in a mouse model that lacked Trpm1 expression