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FLASH GENE
Symbol TRPM1 contributors: mct/shn - updated : 14-06-2016
HGNC name transient receptor potential cation channel, subfamily M, member 1
HGNC id 7146
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ankyrin repeats at the N terminus, and basic N-terminal AA K464 of TRPM1 suggests that it is part of putative pleckstrin homology (PH) domain and is involved in the interactions with INPP5J
  • a core of six transmembrane segments (6TM)
  • a TRP (EWKFHR) domain
  • a small putative transmembrane domain
  • a larger domain with a hollow cavity
  • a C terminal cytoplasmic tail
    • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to Mlsn1, mus musculus
    ortholog to Trpm1, Rattus norvegicus
    Homologene
    FAMILY
  • TRP-melastatin subfamily
    • CATEGORY antigen , receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text long form may be sequestered by MLN-S in the cytoplasm
  • located on the dendrites and soma of retina ON-bipolar cells
  • tips of retina ON-bipolar cell dendrites and rod spherules ribbons
    • basic FUNCTION
  • potential melanoma suppressor
  • involved in sensing taste, ambient temperature, low pH, osmolarity, and chemical ligands
  • role for TRPM1-mediated Ca(2+) homeostasis, which is also regulated by ultraviolet B, in melanogenesis
  • ion channel whose function is critical to normal melanocyte pigmentation
  • important role for the normal function of ON bipolar cells in the human retina
  • GRM6-coupled cation channel in rod-bipolar cells, and is essential for the normal response of cone ON-bipolar cells
  • functional ion-conducting plasma membrane channels
  • expressed on the synaptic ribbons of a subclass of rods, suggesting a dual function for TRPM1 in the ON-pathway
  • is a cation-selective channel, and will therefore depolarize ON bipolar cells when it opens
  • light indirectly opens TRPM1 by reducing transmitter release from presynaptic photoreceptors, resulting in a decrease in GRM6 activation
  • is not essential for development of hearing or balance and it is unlikely that TRPM1 is a component of the hair cell MET channel
  • is essential for the light-induced depolarization of retinal ON bipolar cells
  • the underlying transduction cascade in the dendritic tips of ON-bipolar cells involves GRM6 signaling to TRPM1 proteins that are an indispensable part of the transduction channel
  • calcium channel that is essential for the depolarization of photo-responsive retinal bipolar cells
  • in retinal ON bipolar cells, Go couples the metabotropic receptor GRM6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
  • TRPM1 and TRPM3 form heteromultimeric channels
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRPM1
  • GNB3 participates in the G-protein heterotrimer that couples GRM6 to TRPM1
  • in the retina, TRPM1 activity is negatively coupled to metabotropic GRM6 signaling through Galphao
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation
    • cell & other
    REGULATION
    activated by HIS1 (regulation of both transcription and mRNA processing)
    inhibited by by low micromolar concentrations of Zn2+
    Other downregulated in murine melanoma cell line with an agressive phenotype
    regulated by MITF
    regulated by multiple mechanisms in melanocytes and melanoma cells
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNB1C
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in melanoma with high metastatic potential
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • potential target for pigmentation disorders
    • ANIMAL & CELL MODELS
  • decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both congenital stationary night blindness and coat spotting patterns in horses
  • ON bipolar cell function was absent or severely impaired in a mouse model that lacked Trpm1 expression