| Symbol
| DKK2
| contributors: mct/pgu - updated : 05-01-2017
|
| HGNC name
| dickkopf homolog 2 (Xenopus laevis)
|
| HGNC id
| 2892
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
epigenetically silenced by methylation in higher grades and stages of renal cell carcinoma (RCC)  | | constitutional
|
|
| --low
|
| |
in osteoporosis | | tumoral
|
|
| --over
|
| |
in Ewing sarcoma compared with corresponding normal tissues | | constitutional
|
|
|
| loss of function
| |
resulted in osteopenia because of its role in osteoblast terminal differentiation | |
| Susceptibility
|
to alcohol dependence |
| Variant & Polymorphism
SNP
| rs427983, rs419558, rs399087 associated to alcohol dependence |
|
rs17037102 may be the causal SNP associated with alcohol-related harm in alcoholic subjects |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| diabete | type 2 | | |
| may be a potential therapeutic target for treating type 2 diabetes | | cardiovascular | atheroma | cardiac | |
| may be a viable therapeutic target in the treatment of ischemic vascular diseases |
| | | |