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FLASH GENE
Symbol DKK2 contributors: mct/pgu - updated : 05-01-2015
HGNC name dickkopf homolog 2 (Xenopus laevis)
HGNC id 2892
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
epigenetically silenced by methylation in higher grades and stages of renal cell carcinoma (RCC)
constitutional     --low  
in osteoporosis
tumoral     --over  
in Ewing sarcoma compared with corresponding normal tissues
constitutional       loss of function
resulted in osteopenia because of its role in osteoblast terminal differentiation
Susceptibility to alcohol dependence
Variant & Polymorphism SNP
  • rs427983, rs419558, rs399087 associated to alcohol dependence
  • rs17037102 may be the causal SNP associated with alcohol-related harm in alcoholic subjects
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may be a potential therapeutic target for treating type 2 diabetes
    cardiovascularatheromacardiac
    may be a viable therapeutic target in the treatment of ischemic vascular diseases
    ANIMAL & CELL MODELS