|
| Prss8(-/-) mice lack barrier formation and display fatal postnatal dehydration  | |
liver-specific PRSS8 knockout (LKO) mice develop insulin resistance associated with the increase in hepatic Tlr4 |
|
Prss8-deficient newborns presented abnormal epidermis, and died soon after birth due to impaired skin function |
|
hypomorphic mutations in Prss8, restored placentation and normal development of Spint1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in Spint2-deficient embryos |