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FLASH GENE
Symbol PRSS8 contributors: mct/npt - updated : 01-09-2016
HGNC name protease, serine, 8
HGNC id 9491
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in hormone-refractory prostate cancers
tumoral     --low  
in bladder transitional cell carcinomas is associated with epithelial-mesenchymal transition (EMT), and may have functional implications in tumor invasion and resistance to chemotherapy
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Prss8(-/-) mice lack barrier formation and display fatal postnatal dehydration
  • liver-specific PRSS8 knockout (LKO) mice develop insulin resistance associated with the increase in hepatic Tlr4
  • Prss8-deficient newborns presented abnormal epidermis, and died soon after birth due to impaired skin function
  • hypomorphic mutations in Prss8, restored placentation and normal development of Spint1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in Spint2-deficient embryos